America in the 16th century: Although the Spanish crown claims a monopoly on all trade within its sphere of influence, there are adventurous colonists who venture into the Mayan area to trade in exotic goods such as cocoa beans. In addition, governors, specialists and ambassadors are now in the colonies of Santa Maria: American Kingdoms , which grant bonus abilities and points or change the dice display.

The expansion Santa Maria: American Kingdoms contains additional components and rules for the base game as well as four completely new modules. The four modules can be added individually or in any combination and, among other things, allow five players to play.